University of Wisconsin–Madison
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Wendell Lake Lab

Over the past two decades functional neurosurgery has experienced a significant paradigm shift in the treatment of many conditions, moving from destructive/ablative procedures to therapies involving implantable neurostimulators. Deep brain stimulation (DBS) and vagus nerve stimulation (VNS) are shining examples of the success of neuromodulation therapies, but despite their widespread adoption the mechanisms underlying their efficacy remain unclear. Our goal is to understand how neuromodulation of the central and peripheral nervous system modulates neural activity both in close proximity to the stimulating electrodes and in neural circuits receiving projections from the site of stimulation.