University of Wisconsin–Madison

Mustafa K. Baskaya Lab

Research Interests


  • Microsurgical techniques and training models for neurosurgery education
  • Intinsic anatomy of the brain
  • Neuroanatomy and skull base anatomy
  • Predictors of poor outcome after subarachnoid hemorrhage and vasospasm
  • Predictors of outcome after resection of atypical menengiomas
  • Neuropsychological outcomes after treatment of intracranial aneurysms.

  Baskaya Lab collage

Current Personnel

Name Start Date Position
Nese Keser  8/1/15 Research Fellow
Kabir Bedi 1/22/17 Undergrad
Sara Sayyahmelli 9/15/17 Research Fellow
Deep Bhogilal Patel 6/19/18 Undergrad
Abdurrahman Aycan 8/15/18 Research Fellow
Noah Leiobold 9/5/18 Medical Student
Paul Rowley 10/1/18 Medical Student
Ufuk Erginoglu 10/15/18 Research Fellow
Xinpu Chen 10/15/18 Research Fellow
Walid Ahmed 10/22/18 Research Fellow
Yinfu Xu 11/15/18 Research Fellow

Past Personnel

 

Name Start Date End Date Position
Yusuf Izci 9/1/06 8/1/07 Research Fellow
Ozkan Ates 4/1/07 10/1/07 Research Fellow
Tomer Hananya  9/1/07 8/31/12 Undergraduate
Kutluay Uluc 1/1/08 6/30/12 Research Fellow
Hakan Seckin 2/21/08 3/31/09 Research Fellow
Yurdal Seraslan 8/28/08 3/28/09 Research Fellow
Ilkan Tatar  1/1/09 1/1/10 Research Fellow
Erinc Akture  6/1/09 10/1/11 Research Fellow
Erhan Turkoglu 7/1/09 1/1/10 Research Fellow
Hayri Kertmen 7/2/09 1/1/10 Research Fellow
Erkin Ozgiray 9/30/10 10/24/11 Research Fellow
Almaz Kurbanov 4/1/11 7/1/11 Research Fellow
Mike (Sung) Ha 6/1/11 7/4/12 Research Fellow
Melih Bozkurt 6/23/11 6/22/12 Research Fellow
Gabriel Neves 9/1/11 6/30/15 Undergraduate
Kanaklakshmi Masodkar 9/15/11 1/15/12 Research Fellow
Suat Canbay 10/10/11 3/1/12 Research Fellow
Feda Makkiyah 3/25/12 3/24/13 Research Fellow
Alireza Sadighi 3/26/12 3/25/15 Research Fellow
Ahmet Ozen 6/20/12 8/20/12 Hon. Associate
Veysel Antar 7/6/12 1/5/13 Research Fellow
Bora Gurer 10/1/12 4/30/13 Research Fellow
Mehmet Ali Ekici  10/5/12 10/3/13 Research Fellow
Damla Ozmen 6/1/13 8/30/13 Medical Student
Collin Liu 6/2/13 8/11/13 Hon. Associate
Abdullah Keles 6/30/13 8/30/13 Hon. Associate
Sanser Gul 7/1/13 10/1/13 Honorary Fellow
Enes Efendioglu 7/6/13 7/6/13 Medical Student
Rami Ahmad Fakih 7/17/13 8/15/13 Medical Student
Seyit Kagan Basarslan 8/1/13 10/31/13 Research Fellow
Angela Hanel Antoniazzi 9/30/13 6/30/14 Hon. Associate
Tevfik Yilmaz 10/1/13 9/1/14 Research Fellow
Guner Menekse 1/6/14 4/6/14 Research Fellow
Mehmet Emre Gunaydin 1/15/14  1/15/15 Research Fellow
Zeynep Ceyhan  2/14/14 3/14/14 Medical Student
Alice Kirst 3/5/14 10/31/14 Hon. Associate
Abdulbaki Kozan 6/15/14 6/14/17 Research Fellow
Zeynep Kutlu 6/25/14 7/25/14 Medical Student
Onur Acis 6/25/14 8/20/14 Hon. Associate
Gregory Kujoth  7/6/14 7/6/15 Scientist
Nazan Akkaya 7/15/14  8/13/14 Hon. Associate
Qazi Muhammad Zeeshan 8/1/14 8/1/15 Research Fellow
Laila Faizi, MS 8/18/14 12/15/14 Medical Student
Mehmed Resid Onen 10/1/14 3/31/15 Research Fellow
Abdullah Karakoc 10/9/14 4/9/15 Research Fellow
Joshgun Mammadov 12/1/14 6/30/15 Research Fellow
Arman Quraishi   1/1/15  6/1/2015 Undergrad
Ahmed  Anan Helal 3/1/15 4/30/15 Research Fellow
Pinar Aydin  5/11/15 6/10/15 Research Fellow
Hüseyin Ozevren  6/1/15 7/31/15 Research Fellow
Melih Eroksuz 6/20/15  8/25/15 Hon. Associate
Hatice Koc 6/23/15 9/19/15 Hon. Associate
Natice Nur Kog 6/23/15 9/19/15 Medical Student
Ahmet Yasin Yitik 6/29/15 8/30/15 Hon.Associate Medical Student
Chazz Bracey 7/1/15 6/30/16 Undergraduate
Eric Tarula 7/1/15  6/30/2016 Medical Student
Ullanat Ramesh Menon 7/27/15 7/27/16 Research Fellow
Deniz Morkan 7/31/15 8/29/15 Hon.Associate Medical Student
Abdulfettah Tümtürk 8/28/15 11/30/15 Research Fellow
Burçak Söylemez 10/1/15 10/1/16 Research Fellow
Dila Zafer 10/14/15 10/14/15 Research Fellow
Yahya Turan 10/14/15 10/13/16 Research Fellow
Nural Celik 11/1/15 10/31/16 Research Fellow
Rauf Nasirov 12/1/15 2/29/16 Research Fellow
Azze Ngo 12/12/15 1/1/16 Hon. Associate
Maryam Yavas 12/20/15 1/2/16 Undergraduate
Umut Ocak 1/1/16  9/30/17 Research Fellow
Ilhan Aydin 3/15/16 1/14/17 Research Fellow
Nickolas De Oliveira 3/29/16 6/30/16 Undergraduate
Berkhan Genç 4/1/16 4/30/16 Hon. Associate
Emel Avci 4/1/16 4/30/16 Research Fellow
Yiğit Ünlü 5/1/16 8/19/16 Medical Student
Derya Karataş 6/1/16 6/1/16 Research Fellow
Emel Avcı 6/1/16 6/1/16 Research Fellow
Seyma Karaca  6/1/16 8/30/16 Medical Student
Yağmur Ersoy  6/1/16 8/30/16 Medical Student
Ali Osman Saylak 6/1/16 8/31/16 Medical Student
Ismail Gulsen 6/1/16 6/1/17 Research Fellow
Halil Olgun Peker 6/1/16  12/01/2016 Research Fellow
Onur Erk Taparlı  6/9/16 7/9/16 Medical Student
Mahmut Salih Genc  6/12/16 8/20/16 Medical Student
Berham Genc 6/12/16 8/20/16 Medical Student
Cagin Uryol 6/15/16 7/15/16 Medical Student
Çağın Hüryol  6/15/16  7/15/2016 Medical Student
Sepideh Chagharvand 6/30/16 7/1/17 Research Fellow
Alperen Sirin 7/1/16 8/15/17 Medical Student
Ozde Bilici 7/4/16 7/29/16 Medical Student
Cisel Akpinar 7/16/16 7/21/18 Medical Student
Cem Dinc 8/1/16 7/31/17 Research Fellow
Balkan Sahin 8/15/16 2/14/17 Research Fellow
Omer Ozdemir 9/1/16 10/31/16 Research Fellow
Sahin Hanalioglu 9/1/16 11/30/16 Research Fellow
Sima Sayyahmelli 9/1/16 9/1/17 Research Fellow
Pinar Ocak 10/1/16  9/30/17 Research Fellow
Gokhan Cavus 11/1/16  11/30/2017 Research Fellow
Omer Selcuk 1/1/17 5/13/18 Research Fellow
Abby Sursch  1/5/17 6/30/17 Medical Student
Brzeczkowsk, Andrea 1/17/17 5/12/17 Undergraduate
Ihsan Dogan 1/23/17 1/22/18 Research Fellow
Tyler Jackson 3/2/17 9/30/17 Medical Student
Ahmed AlBayar 3/15/17 9/14/17 Medical Student
Burak Ozdemir 3/15/17 9/14/17 Research Fellow
Aygun Asgarli  3/27/17 7/1/17 Medical Student
Isidro Miches  4/11/17 5/11/17 Medical Student
Burak Ozdemir 4/15/17 4/15/17 Research Fellow
Megan Nedden  6/1/17 8/31/17 Medical Student
Dila Zafer 6/1/17 12/31/17 Research Fellow
Onur Taparli 6/19/17 7/21/17 Medical Student
Cansu KIZILTAŞ 6/26/17  8/26/17 Medical Student
Durdane Yagmur Ersoy 7/1/17 7/31/17 Medical Student
Kylee Karzen 7/1/17 12/31/17 Medical Student
Burcak Soylemez  7/1/17 12/31/17 Research Fellow
Igatius Esene 7/15/17 6/15/18 Research Fellow
Ela Bicki 7/19/17  7/28/17 Medical Student
Tyler Jacobson 7/31/17 1/31/18 Medical Student
Sirin, Alperen  8/1/17 12/31/17 Medical Student
Sara Homig 8/31/17 12/15/17 Undergraduate
Luis Requea-Requena 9/7/17 3/7/18 Research Fellow
Ona Lapteva  12/1/17 1/31/18 Research Fellow
Jelena Scherbak 12/1/17 1/31/18 Research Fellow
Eric Jennings Simoes 2/1/18 6/1/18 Research Fellow
Carla Nankervis  3/2/18 6/30/18 Medical Student
Adi Ahmetspahic  4/15/18 5/14/18 Research Fellow
Mehmet Can Ezgu 6/15/18 7/26/18 Research Fellow
Tolga Sangoz  6/25/18 7/27/18 Medical Student
Elif Ezgi Cemberlitas  6/25/18 8/17/18 Medical Student
Buse Duru Dikmen 7/2/18 8/31/18 Medical Student
Dilara Asar 7/15/18 8/15/18 Medical Student
Nurhayat Karakaya  7/30/18 8/19/18 Medical Student
Cafer Ikbal Gulsever 8/1/18 8/31/18 Medical Student
Ulas Cikla 6/15/12 4/22/19 Scientist, Lab Manager

Recent Research Publications


Gross Total Resection of Large Cerebellopontine Angle Meningioma with a Supratentorial Extension via Retrosigmoid Approach with Suprameatal Drilling and Tentorial Sectioning.

Sayyahmelli S, Ahmetspahic A, Baskaya MK.

J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S399-S401. doi: 10.1055/s-0038-1669973. Epub 2018 Sep 25.

PMID: 30456040

 

A novel, low-cost, reusable, high-fidelity neurosurgical training simulator for cerebrovascular bypass surgery.

Cikla U, Sahin B, Hanalioglu S, Ahmed AS, Niemann D, Baskaya MK.

J Neurosurg. 2018 May 11:1-9. doi: 10.3171/2017.11.JNS17318. [Epub ahead of print]

 

High-resolution diffusion tensor magnetic resonance imaging of the brainstem safe entry zones.

Mukherjee D, Antar V, Soylemez B, Cikla U, Gürer B, Ekici MA, Field AS, Shahriar Salamat M, Başkaya MK.

Neurosurg Rev. 2018 Aug 22. doi: 10.1007/s10143-018-1023-4. [Epub ahead of print]

PMID: 30136133

 

Microsurgical Gross Total Resection of a Large Residual/Recurrent Vestibular Schwannoma via Translabyrinthine Approach.

Sayyahmelli S, Roche J, Baskaya MK.

J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S387-S388. doi: 10.1055/s-0038-1669971. Epub 2018 Sep 25.

PMID: 30456034

 

Hypertrophic Olivary Degeneration: Neurosurgical Perspective and Literature Review.

Onen MR, Moore K, Cikla U, Ucer M, Schmidt B, Field AS, Baskaya MK.

World Neurosurg. 2018 Apr;112:e763-e771. doi: 10.1016/j.wneu.2018.01.150. Epub 2018 Jan 31. Review.

PMID: 29382617

 

Microsurgical Resection of Anaplastic Ependymoma of the Cerebellopontine Angle in an Adult: 3-Dimensional Operative Video.

Sayyahmelli S, Baskaya MK.

Oper Neurosurg (Hagerstown). 2018 Oct 5. doi: 10.1093/ons/opy217. [Epub ahead of print]

PMID: 30295880

 

Mapping of the internal capsule with subcortical stimulation for gross-total resection of a thalamic metastatic tumor.

Sayyahmelli S, Aydin I, Wheeler B, Baskaya MK.

Neurosurg Focus. 2018 Oct;45(VideoSuppl2):V7. doi: 10.3171/2018.10.FocusVid.18267.

PMID: 30269558

 

Frontal lobe intracerebral schwannoma mimicking metastatic lesion in a patient with papillary thyroid carcinoma.

Sayyahmelli S, Kina H, Ucer M, Salamat MS, Baskaya MK.

J Surg Case Rep. 2018 Aug 20;2018(8):rjy212. doi: 10.1093/jscr/rjy212. eCollection 2018 Aug.

PMID: 30151105

 

Gross Total Resection of a Jugular Foramen Thyroid Medullary Metastasis via a Transjugular Transsigmoid Approach.

Aydin I, Sayyahmelli S, Pyle M, Baskaya MK.

J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S424-S425. doi: 10.1055/s-0038-1669970. Epub 2018 Sep 25.

 

Microsurgical Resection of Posterior Third Ventricular/Pineal Region Papillary Tumor Via Supracerebellar Infratentorial Approach: 3-Dimensional Operative Video.

Sayyahmelli S, Dogan I, Baskaya MK.

Oper Neurosurg (Hagerstown). 2018 Dec 1;15(6):E87. doi: 10.1093/ons/opy133.

PMID: 29788336

Calcifying Pseudoneoplasm of the Neuraxis (CAPNON) in Lateral Cerebellomedullary Junction: Clinical Image with Surgical Video.

 

Peker HO, Aydin I, Baskaya MK.

World Neurosurg. 2018 Jul;115:206-207. doi: 10.1016/j.wneu.2018.04.115. Epub 2018 Apr 26.

PMID: 29704692

 

The Tonsillouvular Fissure Approach: Access to Dorsal and Lateral Aspects of the Fourth Ventricle.

Aydin I, Hanalioglu S, Peker HO, Turan Y, Kina H, Cikla U, Baskaya MK.

World Neurosurg. 2018 Jun;114:e1107-e1119. doi: 10.1016/j.wneu.2018.03.157. Epub 2018 Mar 31.

PMID: 29609087

 

Gross Total Resection of Chordoid Glioma of the Third Ventricle via Anterior Interhemispheric Transcallosal Transforaminal Approach at Two Stages.

Dogan I, Ucer M, Başkaya MK.

J Neurol Surg B Skull Base. 2018 Apr;79(Suppl 3):S281-S282. doi: 10.1055/s-0038-1625967. Epub 2018 Feb 16.

PMID: 29588902

 

Microsurgical Resection of Large Thoracic Intramedullary Hemangioblastoma With Long Segment Syrinx: 3-Dimensional Operative Video.

Sayyahmelli S, Baskaya MK.

Oper Neurosurg (Hagerstown). 2018 Oct 1;15(4):470. doi: 10.1093/ons/opx296. No abstract available.

PMID: 29444282

 

Occipital Artery and Its Segments in Vertebral Artery Revascularization Surgery: A Microsurgical Anatomic Study.

Keser N, Avci E, Soylemez B, Karatas D, Baskaya MK.

World Neurosurg. 2018 Apr;112:e534-e539. doi: 10.1016/j.wneu.2018.01.073. Epub 2018 Jan 31.

PMID: 29360587

 

Transsylvian Resection of Dominant Insular Gliomas: Demonstration of Microsurgical Techniques in Pure Insular vs Insulo-Opercular Gliomas: 3-Dimensional Operative Video.

Cikla U, Swanson KI, Turan Y, Baskaya MK.

Oper Neurosurg (Hagerstown). 2017 Dec 1;13(6):760. doi: 10.1093/ons/opx056. No abstract available.

PMID: 29186609

 

Metastatic prostate adenocarcinoma to intradural foramen magnum.

Peker HO, Celik NC, Cikla U, Baskaya MK.

J Surg Case Rep. 2017 Nov 21;2017(11):rjx185. doi: 10.1093/jscr/rjx185. eCollection 2017 Nov.

PMID: 29181146

 

Overcoming End-to-End Vessel Mismatch During Superficial Temporal Artery-Radial Artery-M2 Interposition Grafting for Cerebral Ischemia: Tapering Technique.

Cikla U, Mukherjee D, Tumturk A, Baskaya MK.

World Neurosurg. 2018 Feb;110:85. doi: 10.1016/j.wneu.2017.10.162. Epub 2017 Nov 6.

PMID: 29122732

 

Minimizing Retraction by Pia-Arachnoidal 10-0 Sutures in Intrasulcal Dissection.

Uluc K, Cikla U, Morkan DB, Sirin A, Ahmed AS, Swanson K, Baskaya MK.

Oper Neurosurg (Hagerstown). 2018 Jul 1;15(1):10-14. doi: 10.1093/ons/opx193.

PMID: 29029292

 

Resection of middle petroclival meningioma via combined anterior transpetrosal and retrosigmoid approaches at two separate stages: 3D operative video.

Dogan I, Ocak PE, Pyle GM, Başkaya MK.

Neurosurg Focus. 2017 Oct;43(VideoSuppl2):V12. doi: 10.3171/2017.10.FocusVid.17379.

PMID: 28967312

 

Microsurgical Resection of Thalamic Astrocytomas Via Anterior Interhemispheric Transcallosal Transchoroidal Approach: Demonstrating of Technique: 3-Dimensional Operative Video.

Peker HO, Aydin I, Dinc C, Baskaya MK.

Oper Neurosurg (Hagerstown). 2018 May 1;14(5):595. doi: 10.1093/ons/opx196. No abstract available.

PMID: 28961966

 

Ruptured Distal Accessory Anterior Cerebral Artery Aneurysm: A case report and literature review.

Sirin A, Cikla U, Uluc K, Baskaya MK.

Turk Neurosurg. 2017 Jul 12. doi: 10.5137/1019-5149.JTN.20424-17.1. [Epub ahead of print]

PMID: 28944940 Free Article

 

End-to-Side and End-to-End Double In Situ Bypass with Submilimeter M4 Branches for Treatment of Ruptured Mycotic Aneurysm: 3-Dimensional Operative Video.

Turan Y, Cikla U, Kozan A, Baskaya MK.

Oper Neurosurg (Hagerstown). 2017 Oct 1;13(5):642. doi: 10.1093/ons/opx005. No abstract available.

PMID: 28922888

 

Emergency resection of brainstem cavernous malformations.

Tumturk A, Li Y, Turan Y, Cikla U, Iskandar BJ, Baskaya MK.

J Neurosurg. 2018 May;128(5):1289-1296. doi: 10.3171/2017.1.JNS161693. Epub 2017 Jul 7.

PMID: 28686112

 

Resection of complex occipital arteriovenous malformation with giant varix: demonstration of microsurgical technique.

Ocak PE, Dinc C, Cikla U, Başkaya MK.

Neurosurg Focus. 2017 Jul;43(VideoSuppl1):V5. doi: 10.3171/2017.7.FocusVid.17125.

PMID: 28669274

 

The Impact of Intracranial Tumor Proximity to White Matter Tracts on Morbidity and Mortality: A Retrospective Diffusion Tensor Imaging Study.

Meyer EJ, Gaggl W, Gilloon B, Swan B, Greenstein M, Voss J, Hussain N, Holdsworth RL, Nair VA, Meyerand ME, Kuo JS, Baskaya MK, Field AS, Prabhakaran V.

Neurosurgery. 2017 Feb 1;80(2):193-200. doi: 10.1093/neuros/nyw040.

PMID: 28173590

 

Microsurgical resection of tumors of the lateral and third ventricles: operative corridors for difficult-to-reach lesions.

Cikla U, Swanson KI, Tumturk A, Keser N, Uluc K, Cohen-Gadol A, Baskaya MK.

J Neurooncol. 2016 Nov;130(2):331-340. Epub 2016 May 27. Review.

PMID: 27235145 Free PMC Article

 

The sulci of the inferior surface of the temporal lobe: An anatomical study.

Cikla U, Menekse G, Quraishi A, Neves G, Keles A, Liu C, Salamat SM, Baskaya MK.

Clin Anat. 2016 Oct;29(7):932-42. doi: 10.1002/ca.22767. Epub 2016 Sep 4.

PMID: 27521775

 

Monitoring Ischemic Cerebral Injury in Spontaneously Hypertensive Rats by Diffusion Tensor Imaging.

Kujoth GC, Neves GF, Cikla U, Akture E, Uluc K, Song C, Hananya T, Sadighi A, Ferrazzano P, Baskaya MK.

Turk Neurosurg. 2016;26(4):500-12. doi: 10.5137/1019-5149.JTN.15192-15.1.

 

Supracerebellar transtentorial approach to the tentorial incisura and beyond.

Swanson KI, Cikla U, Uluc K, Baskaya MK.

Neurosurg Focus. 2016 Jan;40 Video Suppl 1:2016.1.FocusVid.15444. doi: 10.3171/2016.1.FocusVid.15444.

PMID: 26722681

 

Microsurgical Treatment of Thalamic Cavernous Malformation: 3-Dimensional Operative Video.

Yilmaz T, Cikla U, Baskaya MK.

Oper Neurosurg (Hagerstown). 2015 Dec 1;11(4):577. doi: 10.1227/NEU.0000000000000964. No abstract available.

PMID: 29506173

 

Osteopetrosis and Chiari type I malformation: a rare association.

Ekici MA, Cıkla U, Bauer A, Başkaya MK.

J Surg Case Rep. 2015 Oct 26;2015(10). pii: rjv084. doi: 10.1093/jscr/rjv084.

PMID: 26503583

 

Microsurgical clipping of a giant vertebrobasilar junction aneurysm under hypothermic circulatory arrest.

Cıkla U, Uluç K, Baskaya MK.

Neurosurg Focus. 2015 Jul;39 Video Suppl 1:V13. doi: 10.3171/2015.7.FocusVid.14620.

PMID: 26132611

 

Clip Reconstruction of Giant Distal Anterior Cerebral Artery Aneurysm: 3-Dimensional Operative Video.

Cikla U, Yilmaz T, Li Y, Başkaya MK.

Neurosurgery. 2015 Sep;11 Suppl 3:463; discussion 463. doi: 10.1227/NEU.0000000000000834. No abstract available.

PMID: 26080068

 

Treatment of Supraclinoid Internal Carotid Artery Iatrogenic Pseudoaneurym with Extracranial-to- Intracranial Bypass and Trapping: Demonstration of Technique with Video Presentation.

Cikla U, Li Y, Hernandez-Duran S, Kozan A, Baskaya MK.

Turk Neurosurg. 2015;25(2):305-9. doi: 10.5137/1019-5149.JTN.13039-14.1.

PMID: 26014018

 

Glioblastoma multiforme in Klippel-Trenaunay-Weber syndrome: a case report.

Yilmaz T, Cikla U, Kirst A, Baskaya MK.

J Med Case Rep. 2015 Apr 17;9:83. doi: 10.1186/s13256-015-0555-2.

PMID: 25890301

 

Atypical meningioma: randomized trials are required to resolve contradictory retrospective results regarding the role of adjuvant radiotherapy.

Yoon H, Mehta MP, Perumal K, Helenowski IB, Chappell RJ, Akture E, Lin Y, Marymont MA, Sejpal S, Parsa A, Chandler JR, Bendok BR, Rosenow J, Salamat S, Kumthekar P, Raizer JK, Baskaya MK.

J Cancer Res Ther. 2015 Jan-Mar;11(1):59-66. doi: 10.4103/0973-1482.148708.

PMID: 25879338

 

Ruptured Posterior Communicating Artery Aneurysm Associated with Aarskog Syndrome.

Cıkla U, Giampietro PF, Sadighi A, Başkaya MK.

NMC Case Rep J. 2015 Feb 20;2(3):85-87. doi: 10.2176/nmccrj.2014-0022. eCollection 2015 Jul.

PMID: 28663972

 

Surgical treatment of adult moyamoya disease with combined STA-MCA bypass and EDAS: demonstration of technique in video presentation.

Li Y, Cikla U, Baggott C, Yilmaz T, Chao C, Baskaya MK.

Turk Neurosurg. 2015;25(1):126-31. doi: 10.5137/1019-5149.JTN.12829-14.0.

 

Clip reconstruction of an 8 cm giant internal carotid artery bifurcation aneurysm: microsurgical technique.

Cikla U, Uluc K, Baskaya MK.

Neurosurg Focus. 2015 Jan;38(VideoSuppl1):Video20. doi: 10.3171/2015.V1.FOCUS14618.

PMID: 25554843

 

Fatal Ruptured Blood Blister-like Aneurysm of Middle Cerebral Artery Associated with Ehlers-Danlos Syndrome Type VIII (Periodontitis Type).

Cıkla U, Sadighi A, Bauer A, Başkaya MK.

J Neurol Surg Rep. 2014 Dec;75(2):e210-3. doi: 10.1055/s-0034-1387185. Epub 2014 Aug 11.

PMID: 25485215

 

The cadaveric perfusion and angiography as a teaching tool: imaging the intracranial vasculature in cadavers.

Turkoglu E, Seckin H, Gurer B, Ahmed A, Uluc K, Pulfer K, Arat A, Niemann D, Baskaya MK.

J Neurol Surg B Skull Base. 2014 Dec;75(6):435-44. doi: 10.1055/s-0034-1386653. Epub 2014 Aug 11.

PMID: 25452903

 

Microsurgical anatomy of the posterior median septum of the human spinal cord.

Turkoglu E, Kertmen H, Uluc K, Akture E, Gurer B, Cikla U, Salamat S, Başkaya MK.

Clin Anat. 2015 Jan;28(1):45-51. doi: 10.1002/ca.22490. Epub 2014 Dec 1.

PMID: 25445255

 

Familial perimesencephalic subarachnoid hemorrhage: two case reports.

Cıkla U, Aagaard-Kienitz B, Turski PA, Menekse G, Niemann DB, Başkaya MK.

J Med Case Rep. 2014 Nov 22;8:380. doi: 10.1186/1752-1947-8-380.

PMID: 25416614 Free

 

How I do it: treatment of blood blister-like aneurysms of the supraclinoid internal carotid artery by extracranial-to-intracranial bypass and trapping.

Cıkla U, Baggott C, Başkaya MK.

Acta Neurochir (Wien). 2014 Nov;156(11):2071-7. doi: 10.1007/s00701-014-2212-8. Epub 2014 Sep 9.

PMID: 25196640

 

Microsurgical anatomy and variations of the anterior clinoid process.

Dagtekin A, Avci E, Uzmansel D, Kurtoglu Z, Kara E, Uluc K, Akture E, Baskaya MK.

Turk Neurosurg. 2014;24(4):484-93. doi: 10.5137/1019-5149.JTN.8738-13.1.

PMID: 25050671

 

The determination and comparison of the vascular configurations of the posterior cerebral and posterior communicating arteries by two different techniques.

Kertmen H, Gürer B, Uluç K, Turkoglu E, Cikla U, Salamat S, Başkaya MK.

J Neurosurg Sci. 2016 Dec;60(4):430-7. Epub 2014 Mar 18.

PMID: 24637416

 

A stepwise illustration of the retrosigmoid approach for resection of a cerebellopontine meningioma.

Cıkla U, Kujoth GC, Başkaya MK.

Neurosurg Focus. 2014 Jan;36(1 Suppl):1. doi: 10.3171/2014.V1.FOCUS13445.

PMID: 24380520

 

Intraoperative dynamic assessment of the posterior communicating artery and its branches by indocyanine green videoangiography.

Gürer B, Antar V, Cikla U, Bauer A, Baskaya MK.

Surg Neurol Int. 2013 Sep 25;4:122. doi: 10.4103/2152-7806.118936. eCollection 2013.

PMID: 24232934

 

Microsurgical anatomy of the denticulate ligaments and their relationship with the axilla of the spinal nerve roots.

Gürer B, Canbay S, Bozkurt M, Cikla U, Hananya T, Okut H, Başkaya MK.

Clin Anat. 2014 Jul;27(5):733-7. doi: 10.1002/ca.22292. Epub 2013 Jul 26.

PMID: 23897545

 

The subparietal and parietooccipital sulci: an anatomical study.

Gürer B, Bozkurt M, Neves G, Cikla U, Hananya T, Antar V, Salamat S, Başkaya MK.

Clin Anat. 2013 Sep;26(6):667-74. doi: 10.1002/ca.22277. Epub 2013 Jun 27.

PMID: 23813655

 

A case series of primary central nervous system posttransplantation lymphoproliferative disorder: imaging and clinical characteristics.

Lake W, Chang JE, Kennedy T, Morgan A, Salamat S, Başkaya MK.

Neurosurgery. 2013 Jun;72(6):960-70; discussion 970. doi: 10.1227/NEU.0b013e31828cf619.

PMID: 23685504

 

Anatomical relationship and positions of the lumbar and sacral segments of the spinal cord according to the vertebral bodies and the spinal roots.

Canbay S, Gürer B, Bozkurt M, Comert A, Izci Y, Başkaya MK.

Clin Anat. 2014 Mar;27(2):227-33. doi: 10.1002/ca.22253. Epub 2013 May 7.

PMID: 23649511

 

Intracranial blastomycosis presenting as an enhancing cerebellopontine mass.

Akture E, Salamat S, Baskaya MK.

Turk Neurosurg. 2013;23(2):252-5. doi: 10.5137/1019-5149.JTN.4399-11.1.

PMID: 23546914

 

Osteotomy for laminoplasty without soft tissue penetration, performed using a harmonic bone scalpel: instrumentation and technique.

Nickele C, Hanna A, Baskaya MK.

J Neurol Surg A Cent Eur Neurosurg. 2013 May;74(3):183-6. doi: 10.1055/s-0032-1328958. Epub 2013 Mar 15.

PMID: 23504672

 

How reliable and accurate is indocyanine green video angiography in the evaluation of aneurysm obliteration?

Özgiray E, Aktüre E, Patel N, Baggott C, Bozkurt M, Niemann D, Başkaya MK.

Clin Neurol Neurosurg. 2013 Jul;115(7):870-8. doi: 10.1016/j.clineuro.2012.08.027. Epub 2012 Sep 7.

PMID: 22959212

 

A stepwise illustration of the translabyrinthine approach to a large cystic vestibular schwannoma.

Nickele CM, Akture E, Gubbels SP, Başkaya MK.

Neurosurg Focus. 2012 Sep;33(3):E11. doi: 10.3171/2012.7.FOCUS12208. Review.

PMID: 22937845

 

Demographic, circadian, and climatic factors in non-aneurysmal versus aneursymal subarachnoid hemorrhage.

Miranpuri AS, Aktüre E, Baggott CD, Miranpuri A, Uluç K, Güneş VE, Lin Y, Niemann DB, Başkaya MK.

Clin Neurol Neurosurg. 2013 Mar;115(3):298-303. doi: 10.1016/j.clineuro.2012.05.039. Epub 2012 Jul 6.

PMID: 22770541

 

Anatomy of Meckel’s cave and the trigeminal ganglion: anatomical landmarks for a safer approach to them.

Arslan M, Deda H, Avci E, Elhan A, Tekdemir I, Tubbs RS, Silav G, Yilmaz E, Baskaya MK.

Turk Neurosurg. 2012;22(3):317-23. doi: 10.5137/1019-5149.JTN.5213-11.1.

PMID: 22664999

 

Microsurgical anatomy of the dorsal thoracic rootlets and dorsal root entry zones.

Bozkurt M, Canbay S, Neves GF, Aktüre E, Fidan E, Salamat MS, Başkaya MK.

Acta Neurochir (Wien). 2012 Jul;154(7):1235-9. doi: 10.1007/s00701-012-1395-0. Epub 2012 Jun 1.

PMID: 22653495

 

Ganglioneuroma of the sphenoid wing: a case report and literature review.

Aktüre E, Salamat MS, Korkmaz H, Baskaya MK.

Clin Neuropathol. 2011 Nov-Dec;30(6):313-7. Review.

PMID: 22011737

 

Application of a new fenestrated clip (Yaşargil T-bar clip) for the treatment of fusiform M1 aneurysm: case illustration and technical report.

Başkaya MK, Uluç K.

Neurosurgery. 2012 Jun;70(2 Suppl Operative):339-42. doi: 10.1227/NEU.0b013e3182330ef7.

PMID: 21869719

 

Anatomical variations of the foramen magnum, occipital condyle and jugular tubercle.

Avci E, Dagtekin A, Ozturk AH, Kara E, Ozturk NC, Uluc K, Akture E, Baskaya MK.

Turk Neurosurg. 2011;21(2):181-90. doi: 10.5137/1019-5149.JTN.3838-10.1.

PMID: 21534200

 

Level I to III craniofacial approaches based on Barrow classification for treatment of skull base meningiomas: surgical technique, microsurgical anatomy, and case illustrations.

Avcı E, Aktüre E, Seçkin H, Uluç K, Bauer AM, Izci Y, Morcos JJ, Başkaya MK.

Neurosurg Focus. 2011 May;30(5):E5. doi: 10.3171/2011.3.FOCUS1110.

PMID: 21529176

 

Focal cerebral ischemia model by endovascular suture occlusion of the middle cerebral artery in the rat.

Uluç K, Miranpuri A, Kujoth GC, Aktüre E, Başkaya MK.

J Vis Exp. 2011 Feb 5;(48). pii: 1978. doi: 10.3791/1978.

PMID: 21339721

 

Microsurgical anatomy of the vein of Labbé.

Avci E, Dagtekin A, Akture E, Uluc K, Baskaya MK.

Surg Radiol Anat. 2011 Sep;33(7):569-73. doi: 10.1007/s00276-011-0782-1. Epub 2011 Jan 30.

PMID: 21279640

 

Anterior communicating artery aneurysm associated with an infraoptic course of anterior cerebral artery and rare variant of the persistent trigeminal artery: a case report and literature review.

Turkoglu E, Arat A, Patel N, Kertmen H, Başkaya MK.

Clin Neurol Neurosurg. 2011 May;113(4):335-40. doi: 10.1016/j.clineuro.2010.12.009. Epub 2011 Jan 26.

PMID: 21269759

 

A calcified sellar lesion.

Kertmen H, Turkoglu E, Başkaya MK.

J Clin Neurosci. 2010 Jul;17(7):897, 956. No abstract available.

PMID: 20524214

A young woman with progressive headache after head trauma. Dermoid tumor.

Turkoglu E, Kertmen H, Başkaya MK.

J Clin Neurosci. 2010 Jun;17(6):760, 816. No abstract available.

PMID: 20440885

 

Operating microscopes: past, present, and future.

Uluç K, Kujoth GC, Başkaya MK.

Neurosurg Focus. 2009 Sep;27(3):E4. doi: 10.3171/2009.6.FOCUS09120.

PMID: 19722819

 

Removal of cavernous malformation of the Meckel’s cave by extradural pterional approach using Heros muscle dissection technique.

Seçkin H, Patel N, Avci E, Dempsey RJ, Başkaya MK.

Surg Neurol. 2009 Dec;72(6):733-6; discussion 736. doi: 10.1016/j.surneu.2009.04.007. Epub 2009 Jul 15.

PMID: 19608252

 

A vermian artery originating from the posterior cerebral artery: an anatomical case report.

Serarslan Y, Uluç K, Başkaya MK.

Surg Radiol Anat. 2009 Oct;31(8):645-7. doi: 10.1007/s00276-009-0501-3. Epub 2009 Apr 15.

PMID: 19367355

 

Supracerebellar transtentorial transcollateral sulcus approach to the atrium of the lateral ventricle: microsurgical anatomy and surgical technique in cadaveric dissections.

Izci Y, Seçkin H, Ateş O, Başkaya MK.

Surg Neurol. 2009 Nov;72(5):509-14; discussion 514. doi: 10.1016/j.surneu.2009.01.025. Epub 2009 Mar 27.

PMID: 19328525

 

Microsurgical anatomy of the posterior spinal artery via a far-lateral transcondylar approach.

Seçkin H, Ateş O, Bauer AM, Başkaya MK.

J Neurosurg Spine. 2009 Mar;10(3):228-33. doi: 10.3171/2008.12.SPINE08289.

PMID: 19320582

 

Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in rats.

Liu YP, Seçkin H, Izci Y, Du ZW, Yan YP, Başkaya MK.

J Cereb Blood Flow Metab. 2009 Apr;29(4):780-91. doi: 10.1038/jcbfm.2009.1. Epub 2009 Feb 11.

PMID: 19209181

 

Sulcal and gyral anatomy of the orbitofrontal cortex in relation to the recurrent artery of Heubner: an anatomical study.

Izci Y, Seçkin H, Medow J, Turnquist C, Başkaya MK.

Surg Radiol Anat. 2009 Jul;31(6):439-45. doi: 10.1007/s00276-009-0465-3. Epub 2009 Feb 4.

PMID: 19190845

 

Superficial vascular anatomy of the medial prefrontal cortex: an anatomical study.

Izci Y, Agrawal B, Ateş O, Başkaya MK.

Surg Neurol. 2009 Oct;72(4):383-8. doi: 10.1016/j.surneu.2008.09.010. Epub 2009 Jan 14.

PMID: 19147184

 

The work horse of skull base surgery: orbitozygomatic approach. Technique, modifications, and applications.

Seçkin H, Avci E, Uluç K, Niemann D, Başkaya MK.

Neurosurg Focus. 2008;25(6):E4. doi: 10.3171/FOC.2008.25.12.E4.

PMID: 19035702

 

Retromandibular fossa approach to the high cervical internal carotid artery: an anatomic study.

Izci Y, Moftakhar R, Pyle M, Başkaya MK.

Neurosurgery. 2008 May;62(5 Suppl 2):ONS363-9; discussion 369-70. doi: 10.1227/01.neu.0000326020.07187.6b.

PMID: 18596516

 

Spontaneous acute subdural hematoma as an initial presentation of choriocarcinoma: a case report.

Rocque BG, Başkaya MK.

J Med Case Rep. 2008 Jun 19;2:211. doi: 10.1186/1752-1947-2-211.

PMID: 18565226

 

Microsurgical anatomy of the supracerebellar transtentorial approach to the posterior mediobasal temporal region: technical considerations with a case illustration.

Moftakhar R, Izci Y, Başkaya MK.

Neurosurgery. 2008 Mar;62(3 Suppl 1):1-7; discussion 7-8. doi: 10.1227/01.neu.0000317367.61899.65.

PMID: 18424961

 

Spinal intramedullary cysticercosis of the conus medullaris.

Izci Y, Moftakhar R, Salamat MS, Baskaya MK.

WMJ. 2008 Feb;107(1):37-9.

PMID: 18416368

 

The occipital artery for posterior circulation bypass: microsurgical anatomy.

Ateş O, Ahmed AS, Niemann D, Başkaya MK.

Neurosurg Focus. 2008;24(2):E9. doi: 10.3171/FOC/2008/24/2/E9.

PMID: 18275305

Cerebrovascular Laboratory


Stroke is a major cause of morbidity and mortality in the U.S. population, particularly among aged individuals. Current demographic projections suggest that as the elderly population continues to expand, the need for developing improved treatment options for stroke patients will become even more pressing. Our lab is interested in the molecular events that occur during focal ischemia and in the use of stem cell approaches to improving neurological outcomes following stroke. Our main experimental model involves middle cerebral artery occlusion (MCAO) to generate focal ischemia in spontaneously hypertensive rats (SHR).
 
Over the past several years, we have differentiated green fluorescent protein-expressing human embryonic stem cells (GFP-hESC) into mesenchymal stem cell-like cells (eMSCs). These eMSCs expressed markers (CD-29, CD-44, CD-73, CD-105, CD-166 and Nestin, but not CD-34, C45, CD-106, SSEA-4 or Oct-4) which are consistent with a mesenchymal stem cell state. We have transplanted eMSCs into the femoral veins of SHRs following MCAO. The expression of GFP allows us to follow the migration and further differentiation of the eMSCs in the ischemic brain. We observed migration of the injected eMSCs to the infarction region (Fig. 1) and their subsequent differentiation into neurons (which expressed β-tubulin III, MAP2, HuC and neurofilament) (see Fig. 2) and vascular endothelial cells (which expressed vWF; see Fig. 3). The grafted cells do not appear to differentiate into astrocytes.  

Figure 1Figure 1: Human ES cell-derived mesenchymal stem cells (eMSCs) expressing green fluorescent protein were injected into the femoral vein of rats two days after induction of stroke via middle cerebral artery occlusion. Injected eMSCs migrated to the brain and were found not only in the infarction core (A), but also in the ischemic penumbra as well as remote regions such as cortex and striatum (B, C, D).  eMSCs did not migrate to the contralateral hemisphere (E, F). No GFP-positive cells were observed in the infarction (G) or penumbra (H) regions of PBS-injected control rats.
Figure 2: A subset of transplanted eMSCs (staining positive for GFP and human nuclear antigen) showed evidence of neuronal differentiation (indicated by b tubulin III staining in “Neural Marker” panel) in triple-stained brain sections from the ischemic infarction region two days after injection. Arrows indicate triple-stained cells. (Bar=100µm). Figure 2

Figure 3Figure 3: A subset of transplanted eMSCs (GFP+) showed expression of the endothelial cell marker, von Wildebrand factor (vWF) by 1 week after injection. At 2 weeks, vWF and GFP double-positive cells were observed to form vascular channels. White arrows indicate co-localization of GFP and vWF at 1 week and 2 weeks after transplantation. (Bar=100µm). (vWF positivity was not detected at day 2 after cell transplantation.)

The injected cells survived in the infarction region for at least four weeks after infusion. The infarction volume at 4 weeks post-MCAO was significantly reduced in eMSC transplant recipients relative to that in brains from rats that received only PBS injection. Importantly, post-ischemic behavioral functioning significantly improved in transplant recipients. In these experiments, we found that the engrafted cells did not survive beyond ~4 weeks. The loss of transplanted cells from the infarction region after 4 weeks occurred despite the use of cyclosporin A to suppress the immunological response. We are therefore seeking ways to improve engrafted cell survival in order to enhance the neurogenesis and angiogenesis of the transplanted cells and sustain or improve the neurological recovery of the whole animal. Some approaches include pre-conditioning the eMSCs in culture before transplant, engineering the stem cells to produce specific trophic factors, and treating the SH rats with dietary or pharmaceutical supplements before or after MCAO. We are also interested in determining whether other stem cell types, including induced pleuripotent (iPS) cells may offer greater neurologic protection or longer post-transplant survival.

Anatomical knowledge and microsurgical skills require comprehensive laboratory training before mastering these skills. The study of anatomy goes back over thousands of years. Although we have many technological developments and diverse training models, the importance of handling and dissecting real tissues and organs, has not been changed as a way to learn anatomy. The term “dissection” means “to expose to view.” The dissection laboratory provides an introduction to the variability of the human body and the uniqueness of each cadaver. Furthermore, it is the only place where the surgeons can improve their understanding of the three-dimensional structure of the human body by visual and tactile pathways. University of Wisconsin, Lincoln Ramirez Neurosurgery Operative Skills Laboratory does not only provide neurosurgery residents and fellows to have a rare opportunity to explore anatomy using human cadavers but also gives them the chance of training in spatial appreciation and orientation and in the use of instruments that enhance their eye-hand coordination and manual dexterity. The laboratory is equipped with four fully functional stations that can be used for microdissections simultaneously. Each station has its own set of neurosurgical equipment including an operating microscope, suction, and drills. Whatsmore, in total, there are 8 downdraft tables which can be used as 16 skull-base surgery stations. At each learning stations, residents and fellows can explore and learn anatomy under the tutelage of a teaching assistant. Since the use of formalin is allowed in the lab because it has an adequate ventilation system and downdraft tables, the lab can be used for skull-base surgery courses, spinal and peripheral nerve surgery courses. The lab allows for recording video and still images while performing surgical procedures. In the demonstration station, a faculty performs the specific surgical approach, and the microscopic view (the magnified view of the operative field) is showed in two big screens. The faculty’s position and movements are shown in another big screen. The laboratory is reserved not only for the use of the residents, fellows, and attending staff of the department of neurological surgery, but also it provides excellent collaborations with the other surgical departments in the education field. The Lincoln Ramirez Neurosurgery Operative Skills Laboratory is directed by Dr. Mustafa Baskaya, MD.

Brain Collage Baskaya Lab Collage
Skull Base Course Pamphlet
Figure 6b Figure 5b figure Figure 7
heubner-3 figure figure