BRAIN TUMOR

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EPILEPSY 

Title: Responsive Neurostimulator (RNS) System Pivotal-A Clinical Investigation
Principal Investigator:  Paul Rutecki, MD                     
Co-Investigator:     Karl Sillay, MD                  
Study Sponsor: NeuroPace, Inc. 

A research project testing a new treatment for seizures.  The treatment is the Responsive Neurostimulator (RNS) system which involves implanting a device in the head. When the RNS detects a seizure, it sends electrical signals to your brain.

MOVEMENT DISORDERS

Title: Deep Brain Stimulation Device Battery Life Assessment: Medtronic Soletra and Kinetra
Principal Investigator:  Karl Sillay, MD                       
Study Sponsor: Investigator Initiated

This investigation is a 9-year retroactive chart review of all deep-brain stimulation cases performed at the University of Wisconsin Hospital and Clinics. We hope to uncover trends in stimulation parameters, impulse generator battery characteristics and electrode variations in order to provide insight into the intricacies of deep-brain stimulation technology. This research may provide clinicians with novel guidance and methodology for deep-brain stimulation therapy.

Title: Effects of Deep Brain Stimulation on Decision-Making for Eye Movements in Patients with Parkinson's Disease
Principal Investigator: Karl Sillay, MD                        
Study Sponsor: Investigator Initiated

Parkinson's disease is traditionally considered a disorder of movement; however, certain patients also often experience cognitive symptoms. It has been suggested that DBS may alter performance on cognitive testing. This work seeks to extend recent investigations in humans and non-human primates, to humans with Parkinson's disease being treated with deep-brain stimulation.

Current measures of Parkinsons Disease are subjective in nature.  Without a quantifiable measure, the progression or improvement of the disease can not be classified.  The goal of the study is to quantify tremor movements using a consumer device, the Apple iPod.  Using the iPod, and its integrated accelerometer and gyroscope, the team hopes to quantify patient movements and correspond them to existing outcomes measures (Unified Parkinsons Disease Rating Scale).

PEDIATRICS

SPINE

Title: Development of a web-based registry for evaluating the comparative effectiveness of various treatments for lumbar spine pathology in the wisconsin poulation
Principal Investigator: Daniel Resnick, MD /B. Agrawal, MD                     
Sponsor:  AANS                               

STROKE

Title:  Structural Stability of Carotid Plaque and Symptomatology                                                
Principal Investigator: Robert Dempsey, MD                   
Sponsor: National Institutes of Health

A research project looking at the differences in the plaque in people with symptomatic and asymptomatic carotid stenosis (narrowing of the carotid arteries).  The study uses various techniques to look at the differences in people who have carotid stenosis and the causes and consequences of carotid stroke.

Title: Researching AXIUM™ Coiling Experience and Recanalization (RACER) Study                                         
Principal Investigator: David Niemann, MD            
Study Sponsor:  ev3 Neurovascular

The ev3 Researching AXIUM™ Coiling Experience and Recanalization (RACER) Study is a single arm, prospective, non-randomized, US multi-center study surveying the continuing safety and effectiveness of AXIUM Coils for the treatment of intracranial saccular aneurysms that have a maximum diameter of 2mm to 20mm and are not amenable to treatment with surgical clipping.

Other

Title:A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Progesterone in Patients with Severe Traumatic Brain Injury (SyNAPSe)
Principal Investigator: Joshua Medow, MD
Sponsor: BHR Pharma, LLC       

The goal of the SyNAPSe trial will study if giving intravenous (i.v.) progesterone within 8 hours of the injury for a total of 120 hours to severe traumatic brain injury patients improves their recovery.