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Title: Chiari Surgery Outcomes Study                                        
Investigator: Bermans J. Iskandar, MD                                 
Study Sponsor: American Syringomyelia and Chiari Alliance Project Inc.                     

A research project collecting pilot data to evaluate surgical approaches and outcomes in surgery for patients with Chiari type I malformation and Syringomyelia.  The study will collect data on the characteristics of subjects who ultimately undergo surgical intervention.  Dr. Iskandar and the University of Wisconsin School of Medicine and Public Health will be the coordinating center collecting and compiling data from 12 clinical sites across the United States.  


Title: The Park-Reeves Syringomyelia Research Consortium (PRSRCC) Study
Investigator: Bermans J.  Iskandar, MD

Study Sponsor: The Park Reeves Syringomyelia Research Consortium

The purpose of this study is to create the Park Reeves Syringomyelia Registry, a multi-institutional, online, comprehensive database to collect and store prospective and retrospective data regarding Chiari I Malformations and Syringomyelia. Results from this study will help better understand the pathogenesis of Syringomyelia and how best to treat it as well as answer long-standing questions regarding the optimal surgical techniques for Chiari Malformation. The University of Wisconsin School of Medicine and Public Health and the American Family Children’s Hospital are one of more than 30 clinical sites across the United States participating in this study.




Title:  Structural Stability of Carotid Plaque and Symptomatology                               
Investigator: Robert J. Dempsey, MD                   
Sponsor: National Institutes of Health identifier: NCT02476396

A research project looking at the differences in the plaque in people with symptomatic and asymptomatic carotid stenosis (narrowing of the carotid arteries).  The study uses various techniques to look at the differences in people who have carotid stenosis and the causes and consequences of carotid stroke.


Title: The MISTIE III trial: Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III
Investigator: Azam S. Ahmed, MD
Sponsor: John Hopkins University coordinating site, National Institutes of Health identifier: NCT01827046

This study is a Phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of Intracerebral Hemorrhage (ICH). The purpose is to determine the efficacy of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove ICH improves functional outcome. The University of Wisconsin School of Medicine and Public Health is one of over 70 locations worldwide participating in this trial.



Title: North American Spine Society (NASS) Spine Registry Pilot
Investigator: Daniel K. Resnick, MD
Sponsor: North American Spine Society

The main purpose for this pilot registry is research and quality improvement for spine care. The NASS Spine Registry Pilot aims to test registry processes ultimately aimed at collecting data to enhance understanding of spine care treatments and their resulting patient outcomes, as well as examine the natural history of spine disorders. 13 site across the U.S are participating in this Pilot study.


Title: The RISCIS trial: A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded, Trial Efficacy and Safety of Riluzole in Acute Spinal Cord Injury. Phase II/III
Investigator: Nathaniel P. Brooks, MD
Sponsor: AOSpine North America, Sponsor/CRO representative monitoring identifier: NCT01597518

This is an international, multi-center, prospective, double-blinded, randomized, placebo-controlled Phase II/III clinical trial to evaluate if Riluzole at a dose of 100 mg BID for the first 24 hours followed by 50 mg BID for 13 days is superior to placebo in subjects with acute traumatic Spinal Cord Injury (SCI).
The study will involve up to 35 investigational sites and enroll 351 subjects (includes 10% allowance for attrition).



Additional Information:

Please contact:

Stephanie Wilbrand, PhD             608-265-9248    

OCT                                              608-265-6507    




Last updated: Fri, 10/16/2015 - 14:08
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